It confers a considerable morbidity and mortality, with severe disease occurring in 20% of diagnosed cases, leading to 5,000 deaths per year. Cases have been imported to the US, Germany, Sweden . (N Engl J Med 1986; 314:20 . A person can become infected when they are exposed to household items or food which have become contaminated with . The Lassa virus is transmitted to humans mainly through handling rats, food or house- Lassa Fever (LHF) is an illness caused due to Lassa virus. The virus can be transmitted from rats to humans, or between people. Lassa fever is an acute viral hemorrhagic illness caused by the Lassa virus. We conclude that ribavirin is effective in the treatment of Lassa fever and that it should be used at any point in the illness, as well as for postexposure prophylaxis. The animal reservoir, or host, of Lassa virus is a rodent of the genus Mastomys, commonly known as the "multimammate rat.". Lassa fever (LF) is on the top-priority infections list of both the Food and Drug Administration (FDA) and World Health Organization (WHO). Lassa Fever: 4 Die, 14 In Isolation Centre In Benue. Lassa fever is a viral, hemorrhagic (causes bleeding) disease found in tropical regions of Africa. Lassa fever is a viral illness that typically occurs in West Africa. Treatment and prophylaxis The antiviral drug ribavirin seems to be an effective treatment for Lassa fever if given early on in the course of clinical illness. Intravenous adminstration of the antiviral drug ribavirin has become the standard of care for treatment of Lassa fever, but data on the efficacy of intravenous riba - virin are limited. Lassa fever is a viral haemorrhagic illness, which is caused by the lassa virus. The original study among Lassa fever Many people who are infected do not show symptoms. I'm part of the health promotion team at MSF's Lassa fever project in Ebonyi State, Nigeria. Lassa fever was first recognized in Lassa, Nigeria, in 1969 and is endemic to West Africa; there are approximately 300,000 cases and 5000 deaths annually [ 4-12 ]. Mastomys rats infected with Lassa virus do not become ill, but they can shed the virus in their urine and faeces. It mostly occurs in West African areas and beyond. What is the treatment for Lassa fever? It is more common in West Africa. Symptoms of Lassa fever typically occur 2-21 days after coming into contact with the virus. Many of those infected by the virus do not develop symptoms. The growth of the market can be attributed to the increasing incidences of Lassa fever, especially in the Middle East and Africa region, backed by lack of sanitation and proper healthcare facilities in the region. Lassa fever is an acute viral haemorrhagic illness caused by the Lassa virus, a member of the arenavirus family of viruses. Lassa fever is not as contagious from person to person as other hemorrhagic fevers, such as that caused by the Ebola virus. 2 Internal Medicine, Universitat de Barcelona, Barcelona, ESP. It has been shown to be most effective when given early in the course of the illness. This review explores the different treatment approaches found in the literature within the last 20 years. Current treatment options are inadequate, relying primarily on supportive care. Lassa fever (LF) is a zoonotic disease associated with acute and potentially fatal haemorrhagic disease caused by Lassa virus (LASV), a member of the Arenaviridae virus family. The virus is the hemorrhagic fever causing a virus having a single-stranded RNA. Here we will discus the history of lassa fever in Nigeria, recent outbreaks, symptoms, states affected, causes, treatment options, prevention and control. People usually become infected with Lassa virus through exposure to food or household items contaminated with urine or . Treatment includes IV ribavirin. The Lassa fever outbreaks happen each and every year and period between December to June is considered its peak season in countries like West Africa. LONDON — Cases of Lassa fever have been identified in the United Kingdom for the first time in over a decade. Also, the company is supplying antibody testing kits to the Coalition for Epidemic Preparedness Innovations (CEPI) for the largest ever Lassa fever study in West Africa. Lassa fever is an acute viral hemorrhagic fever that is usually transmitted to humans from the infected urine or feces of the Mastomys rat. The first confirmed cases of Lassa fever in this country in more than a decade have officially been diagnosed, in a family who recently returned from West Africa.. Health officials have said that another probably case connected to the same family is currently also under investigation - but stressed that the risk to the public from the Ebola-like virus is 'very low'. Lassa fever is a severe viral hemorrhagic disease that was first reported in 1969 in an American missionary nurse who worked in Lassa town in Borno State of Nigeria. It has been shown to be most effective when it is administered early in the course of the illness. Lassa Fever. Lassa fever belongs to a group of viral hemorrhagic fevers and is also termed as Lassa hemorrhagic fever (LHF). Treatment French Ribavirin, an antiviral drug, has been used with success in Lassa fever patients. There is currently no vaccine against the diease. This contagious disease affects many West African countries like Nigeria, Ghana, Benin . "As such, the Ministry has repositioned doses of antiviral agents for the treatment of the Lassa Fever cases and personal protective devices for the health care providers at Iwere lle and Iganna.. The acute febrile illness caused by the virus can last from one to four weeks. Management of bleeding and hydration is critical, especially in hemorrhagic cases. The lassa fever treatment market is segmented on the basis of treatment, route of administration, end-users and distribution channel. Lassa fever is an acute viral haemorrhagic illness caused by Lassa virus. The growth among segments helps you analyse niche pockets of growth and strategies to approach the market and determine your core application areas and the difference in your target markets. According to the World Health Organisation (WHO), it is an acute viral haemorrhagic illness of 21 days duration . Lassa Fever. Since 2015, major increases in Lassa fever attack rate and in the case-fatality rate have occurred in this state. Around 80 percent of people infected with the Lassa virus have no symptoms, but some can develop a severe disease . Lassa fever is a severe viral hemorrhagic disease that was first reported in 1969 in an American missionary nurse who worked in Lassa town in Borno State of Nigeria. Two cases of Lassa fever have been detected in Britain among people who recently returned from West Africa. Health officials revealed the infected patients are members of the same family, who live . An acute zoonotic viral haemorrhagic fever endemic to West Africa. There is currently no vaccine against the diease. Symptoms include fever and damage to multiple organs and the circulatory system. Premium Times Premium Times This was made known by a colleague to the deceased doctor who claimed he treated the two patients and currently isolating and taking medication to prevent the disease.. The U.K. Health Security Agency (UKHSA) confirmed in a press release Wednesday that two people have been diagnosed with Lassa fever in England, while a third "probable case" is under investigation.. All three cases are within the same family in the East of England and are linked . Lassa fever is an acute viral hemorrhagic (excessive bleeding) illness that is transmitted to humans through contact with food, household items contaminated by infected rodents or contaminated . "The Royal Free Hospital is a specialist centre for treating patients with viral hemorrhagic fevers, including Lassa fever," Dr. Sir Michael Jacobs, consultant in infectious diseases at the Royal Free London NHS Foundation Trust, said in a statement Wednesday. Treatment of a patient with Lassa fever will depend on the way the patient presents, and their categorisation as mild or severe. Lassa fever is an acute febrile illness, with bleeding and death in severe cases. It is used in combination with interferon for the treatment of chronic hepatitis C. Frequency (Epidemiology): Lassa fever frequently infects people in West Africa with about 80% being asymptomatic, studies show up to 300, 000 - 500, 000 cases annually and causes about 5,000 deaths. Lassa fever is an acute illness caused by a negative-strand of RNA (Ribonucleic Acid) virus in the family Arenaviridae. Found predominantly in west Africa,1 it has the potential to cause tens of thousands of deaths. Lassa fever was responsible for 10-16% of all adult medical admissions in 1987 in two hospitals studied in Sierra Leone and for about 30% of adult deaths.15The case fatality rate in Kenema varied from 12% to 23% for the period 1997-2002. Diagnosis Typically Lassa fever is diagnosed using enzyme-linked immunosorbent serologic assays (ELISA). Lassa fever is a viral haemorrhagic illness, which is caused by the lassa virus. Lassa fever is an acute viral infection disease just like other hemorrhagic fever viruses such as Ebola virus, Marburg virus etc. Lassa fever, also known as Lassa hemorrhagic fever (LHF), is a type of viral hemorrhagic fever caused by the Lassa virus. It may involve multiple organ systems. People at greatest risk are those who live in West Africa, an endemic region for Lassa fever. Currently, early diagnosis of Lassa fever is key for effective treatment. Signs and symptoms of Lassa fever begin from 6 days to 3 weeks after exposure. Lassa Fever Treatment & Medication Ribavirin (Rebetol, Copegus, Ribasphere, RibaPak, Moderiba) Ribavirin is an antiviral drug. Lassa fever is a viral hemorrhagic fever endemic in parts of West Africa. Lassa fever (a medical condition caused by rodents and mainly occurs in West Africa) is an acute viral haemorrhagic illness that lasts for two to twenty one days; it is transmitted to humans through foods or any household item or office object that is contaminated with the urine or faeces of rodents.. A medical doctor working with the World Health Organisation (WHO) in Benue State has reportedly died of Lassa fever. The News Agency of Nigeria (NAN) reports that Lassa fever is a viral haemorrhagic fever transmitted by rats. At present, no treatment has been developed to specifically treat LF and only one prospective clinical trial has been conducted to evaluate the current treatment recommendation. Other treatment focuses on relieving symptoms and maintaining body function. Lassa fever diagnosis and treatment. According to the state's . Author summary Lassa fever (LF) is an acute viral haemorrhagic fever endemic to West Africa, causing an estimated 500,000 new infections and 10,000 deaths per year. Due to the permeability of blood vessels, pulmonary edema is a concern, and fluid infusion must therefore be carefully monitored. Around 80 percent of people infected with the Lassa virus have no symptoms, but some can develop a severe disease . Read about treatment, prevention and vaccine. It is diagnosed with laboratory tests . Lassa fever is a zoonotic disease, meaning that humans become infected from contact with infected animals. Lassa fever is an acute viral hemorrhagic illness that is transmitted to humans through contact with food or household items contaminated by infected rodents. Lassa fever is a viral infection that causes signs and symptoms that include fever, malaise, headache, and weakness. Objectives: Lassa fever (LF) causes annual outbreaks in endemic regions with high mortality of symptomatic patients. Generally, all patients receive supportive care like intravenous . It has been known since the 1950s, but the virus was not identified until 1969, when two. Ribavirin for the treatment of Lassa fever: A systematic review and meta-analysis Based on the available data, current treatment guidelines may therefore put patients with mild LF at increased risk of death. NCDC issues Lassa fever alert, as death toll hits 102. It has been known since the 1950s, but the virus was not identified until 1969, when two missionary nurses died from it in the town of Lassa in Nigeria. Lassa fever is a viral hemorrhagic fever. Prevention The main focus of. We report the epidemiology of Lassa fever in Bauchi State, a disease-endemic region, in Nigeria. The Oyo State government has set up a surveillance system in all local government areas following an outbreak of Lassa fever in the Iwajowa area of the state. Coupled with that is Zalgen's preclinical therapeutic asset, Arevirumab-3 , a first-in-class immunotherapeutic for prophylaxis and post-exposure treatment of Lassa fever. Health officials revealed the infected patients are members of the same family, who live . Person-to-person transmission can also occur, particularly in healthcare settings when there is the absence of or inadequate infection control measures. Our correspondent reports that the doctor whose name was given as Samuel Tagher Nyitor, succumbed to death on Sunday from the disease after being referred to Irrua Specialist Hospital in Edo State. Treatment: Treatment for Lassa fever is largely symptomatic. Lassa fever diagnosis and treatment. People should also receive supportive care that consists of maintenance of: The Nigeria Centre for Disease Control (NCDC) on Monday issued a warning over Lassa fever cases, which it said had risen to 4,632 and 102 . People usually become infected with Lassa virus through exposure to food or household items contaminated with urine or . In Nigeria, between August 2015 and 17 May 2016 there have been 273 cases of Lassa fever, including 149 Deaths in 23 states. Doctors recommend Ribavirin, an antiviral medication, within the first 6 days of contracting the virus. There is no vaccine against the virus but there is treatment available (Picture: Rex Shutterstock) According to the WHO the anti-viral drug ribavirin is. Prevention Lassa fever: NCDC registers 40 deaths, 4 health workers infected in Jan The NCDC, via its verified website, made this known on Sunday morning, saying that it is currently distributing medical. Loss of fluids from blood vessels and the accumulation of fluids in the lungs can occur in severe illness from Lassa fever. Each year, an estimated 300,000 people are infected, and severe cases can be fatal. Even after recovery, the virus remains in body fluids, including semen.1 The years . Human-to-human transmission is also possible, via contact with the bodily fluids of an infected person. Lassa Fever is a hemorrhagic viral fever caused by a single-stranded RNA Lassa Virus which is a member of the family of Arenaviridae viruses.It lasts for at least one week to four weeks. This includes managing fluid levels, electrolyte balance, oxygenation, and blood pressure. There is no evidence to support the role of ribavirin as post-exposure prophylactic treatment for Lassa fever. Pain management is prescribed through the use of opiates. though overall case-fatality rates for patients with Lassa fever is ≈1%, rates among hospitalized case-patients are >15% (2). Fourteen patients who have been diagnosed with Lassa fever are responding to treatment at the Benue State University Teaching Hospital (BSUTH . that occurs mostly in West Africa. A delay in seeking care by a case-patient for >7 days after symptom onset was the major predictor of death. A small percentage of people infected with Lassa fever will develop complications like hemorrhaging, respiratory distress, tremors, encephalitis, and multi-organ failure. The global Lassa fever treatment market is estimated to grow at a significant CAGR over the forecast period, i.e., 2022 - 2030. The Benue State Ministry of Health and Human Services has slammed Prof. Terhemba Shija, for politicizing the death of Samuel Tagher. The role of ribavirin in the treatment of LF requires urgent reassessment. The cause is the Lassa virus; hence the name "Lassa Fever." Know the causes, signs, symptoms, treatment, prognosis and diagnosis of Lassa Fever. In 2018, there was a large-scale outbreak which prompted MSF to set up the project. Lassa is a viral haemorrhagic fever that's endemic in this area. Management of Lassa Fever: A Current Update Authors Ammar Alli 1 2 , Juan Fernando Ortiz 3 4 , Stephanie P Fabara 5 , Amrapali Patel 6 , Taras Halan 7 Affiliations 1 Medicine, Tishreen University Faculty of Medicine, Lattakia, SYR. Lassa Fever: 4 Die, 14 In Isolation Centre In Benue. It is diagnosed with laboratory tests . The World Health Organisation says humans usually become infected with the Lassa virus through exposure to food or household items contaminated with urine or faeces of infected Mastomys rats. It belongs to the Arenaviridae family. It includes a . Patient has not responded to standard anti-malaria treatment and treatment for other common infectious causes of fever within 48-72 hours b. Lassa fever is an acute viral hemorrhagic illness caused by Lassa virus. When symptoms occur they typically include fever, weakness, headaches, vomiting, and muscle pains. A person can become infected when they are exposed to household items or food which have become contaminated with . Two cases of Lassa fever have been detected in Britain among people who recently returned from West Africa. Fourteen patients who have been diagnosed with Lassa fever are responding to treatment at the Benue State University Teaching Hospital (BSUTH . The disease is primarily spread to humans through exposure to rodents, but nosocomial spread can also occur. People usually become infected with Lassa virus through exposure to food or household items contaminated with urine or . Lassa fever is a hemorrhagic illness caused by Lassa virus [ 1-3 ]. Ribavirin is recommended as standard treatment for LF in national and . Lassa fever is an acute viral haemorrhagic illness caused by Lassa virus. In this post, we will look at Lassa Fever in Nigeria. diarrhea. Less commonly there may be bleeding from the mouth or gastrointestinal tract. Lassa fever is an acute viral hemorrhagic illness caused by the Lassa virus. It is endemic in several West African countries and occurs sporadically as well as in annual outbreaks ( Fichet-Calvet and Rogers, 2009 ). It is caused by infection with the Lassa virus, a single-stranded RNA virus that belongs to the Arenaviridae family of viruses (genus: Mammarenavirus).The natural reservoir is the multimammate rat (Mastomys natalensis), a rodent found commonly in rural areas of tropical Africa that often colonises in or around human homes where . Treatment Ribavirin has been used with success in Lassa fever patients. What are the symptoms of Lassa fever? Diagnosis is with serologic tests and polymerase chain reaction (PCR). Treatment for Lassa Fever Ribavirin, is an antiviral drug that has been used with success in people affected by Lassa fever. Tagher, a medical doctor, died a few days ago of Lassa fever in . Symptoms associated with the condition can include. The symptoms of Lassa fever are widely different in every case and the diagnosis can be difficult due to this reason. ringing in the ears. The antiviral drug ribavirin appears to be an effective treatment for Lassa fever if given early in the course of the illness, the WHO says. The symptoms of Lassa fever are widely different in every case and the diagnosis can be difficult due to this reason. There is currently no vaccine that protects against Lassa fever. Even though ribavirin stands out among medication options, only one clinical trial was done to assess its efficacy in humans, which necessitated that . The animal reservoir is the rodent "multimammate rat" ( Mastomys natalensis ); transmission to humans occurs via . Lassa fever outbreaks have occurred in Nigeria, Liberia, Guinea, Togo, Benin, Ghana, and Sierra Leone. Early treatment and diagnosis increase the chances of survival." report noted, "Lassa fever presents initially like any other febrile illness such as malaria. Lassa fever is a viral haemorrhagic fever transmitted by rats. The antiviral drug ribavirin appears to be an effective treatment for Lassa fever if given early in the course of the illness, the WHO says. Lassa fever in Ebonyi.
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