11. A total of 457 patients with T1-T2 gastric cancer who underwent gastrectomy between 2005 and 2015 were enrolled in this retrospective study. Globally, gastric cancer is the fourth most common malignant tumor and the second highest cause of cancer-related mortalities ( 1 - 3 ). Relevant articles were identified in the MEDLINE, Science Citation Index, Cochrane Library, PubMed, EMBASE, CINAHL . Gastric cancer (GC) is the third leading cause of cancer mortality worldwide ().The GC incidence shows strong geographic variations, with the highest incidence in East Asia, especially Japan and Korea ().Although there are several reports that suggest hereditary and lifestyle factors, including strains of Helicobacter pylori (H. pylori), as contributors to these geographic . The incidence among Japanese, Korean, and Iranian males were 66.7, 64.6, and 30.4%, respectively. The Asian population of the United States (US) is growing rapidly and over 17 million Americans are of Asian descent. The aim was to conduct a meta-epidemiological MA (MEMA) to evaluate association between excess body weight and the risk of gastric cancer in Asian adults with using the proposed classification of weight by body mass . The Asian population of the United State s (US) is gro wing rapidly and over 17 million. The rate is lowest in North and East Africa, with only 4.7 annual diagnoses per 100,000 males. Although the age standardised rates of gastric cancer have been declining for decades, the absolute numbers are increasing because of the rapid aging of the population. Asian Americans, the fastest growing minority population in the US, have higher gastric cancer survival than . Guihua Liu 1# , Ming Xu 2#, Tingting Gao 1, Lingying Xu 1, Peijun Zeng 1, Haiying Bo 1, Fang Li 1, Wei Zhang 1, Zhengting Wang 3 . and their importance in gastric cancer susceptibility. According to official Japanese statistics, 9.3% of Japan's population was estimated to be ≥ 80 years in 2021 [].With the aging trend of the population, patients with gastric cancer are also aging. Stomach cancer mortality. Gastric cancer (GC) poses a burden to patients across the globe as the third leading cause of cancer deaths worldwide. In East Asia, the average incidence of gastric cancer is 32.1 per 100,000 among males and 13.2 among females. Risk factors for stomach cancer include H. pylori infection, smoking, and ingestion of salt-preserved foods [ 1, 19 ]. Hua HB, Yan TT, Sun QM. Lu R (1), Dou X, Gao X, Zhang J, Ni J, Guo L. Author information: (1)Department of Clinical Laboratory, Fudan University Shanghai Cancer Center, Shanghai, China. Methods Between July 2004 and December 2006, 116 patients . 2005 Oct;20(10):1603-9. doi: 10.1111/j.1440-1746.2005.03898.x. Therefore, this study was designed to analyze surgical treatment outcomes of T1-T2 gastric cancer in elderly patients. Therefore, the meta-analysis suggests that null genotype of GSTT1 contributes to increased risk of gastric cancer in Asian population. Furthermore, we also conduct a simple meta-analysis about most frequently studied miRNA-SNPs (rs11614913 in miR-196a-2, rs895819 in miR-27a and rs2910164 in miR-146a) in gastric cancer. GC is more prevalent in less developed countries than in more developed countries. These rates are age-adjusted and based on 2014-2018 cases and 2015-2019 deaths. Asian Pac J Cancer Prev. Salt processed food and gastric cancer in a Chinese population. A functional polymorphism of lymphotoxin-alpha (LTA) gene rs909253 is associated with gastric cancer risk in an Asian population. Liver and stomach cancer occur at higher rates within the Asian American community. Stomach and Liver Cancer. A comprehensive literature was conducted and 27 case-control . According to 2015 statistics, nearly 679,100 new cases of GC and 498,000 new mortalities due to GS were diagnosed in China (2). The death rate was 2.9 per 100,000 men and women per year. and their importance in gastric cancer susceptibility. Gastric cancer (GC) is the fourth most common cancer in the world with more than 70% of cases occur in the developing world. Incidence among Asian subpopulations is highest among Koreans followed by Japanese and Vietnamese, reflecting in part that worldwide stomach cancer rates are highest in Korea [ 1 ]. 2014;15(13):5293-5298. Background: Studies investigating the association between p53 codon 72 polymorphism and gastric cancer risk report conflicting results. Running Head: GASTRIC CANCER IN THE ASIAN COMMUNITY Disparity Critique Paper Crystal Lee Wilkes University NURS 556: Health Perspectives of Gastric cancer is the fourth most common cancer in the world and second most common reason for cancer related death. In case of nanocurcumin, the inhibition rate increased from 7% to 69% for 24h, 11% to 87% for 48h and 16% to 97% for 72h. 12. miRNA polymorphisms and risk of gastric cancer in Asian population. Colorectal cancer (CRC) is the second most common cause of cancer death with approximately 1.8 million new cases and 826 000 deaths worldwide in 2018.1 The incidence of CRC is estimated to rise to 2.2 million people by 2030, with 1.1 million CRC associated deaths.2 Apart from CRC, gastric cancer (GC) and oesophageal cancer (EC) also pose a . Numerous studies were published to investigate the relationship between the glutathione S-transferase T1 (GSTT1) null genotype and risk of gastric cancer in Asians, but the conclusions from those studies were conflicting. Cancer is the second leading cause of death in the United States, yet trends and current patterns in the mortality burden of cancer among AA ethnic groups have not . miRNA polymorphisms and risk of gastric cancer in Asian population. In contrast, the study conducted by Hishida et al on 583 gastric cancer cases and 540 gastric atrophy cases suggested a lack of association between SNP rs2910164 and gastric cancer risk. View Disparity Paper.pdf from NSG 556 at Wilkes University. Gastric cancer and NPC accounted for 92% (132,199 cases) of all EBV-attributed cancer deaths, with the vast majority occurring in developing countries, in particular East Asia. Intestinal Metaplasia and the Risk of Gastric cancer in an Immigrant Asian population Amir Abadir1, Catherine Streutker2, Christine Brezden-Masley3, Andrea Grin2 and Young-In Kim1,4 1Division of Gastroenterology, Department of Medicine, University of Toronto. [PubMed: 27268620]. AIM: To investigate associations between the IL-17 rs2275913 G>A and rs763780 T>C polymorphisms and susceptibility to gastric cancer in Asian populations.. METHODS: We reviewed studies published up to 2014 on IL-17 polymorphisms with gastric cancer susceptibility systematically. Given that immigrants from countries of high gastric cancer, including Asian Americans and Hispanics, comprise the vast majority of population growth in the United States, the public health implications are enormous if we continue to be complacent on gastric cancer prevention and early detection efforts. Despite the high incidence of gastric cancer in East Asian countries, previous work has suggested that low detection rates for germline CDH1 variants are identified in Asians compared to countries . Gastric cancer (GC) remains the fifth most common type of malignant tumor and is the third leading cause of cancer‑related death in the world (1). About half of all GC cases worldwide occur in East Asia, notably China. Gastric cancer is among the most common malignancies in Asia.1 Despite a high incidence in many Asian nations, population-based studies indicate that Asian-American patients have improved gastric cancer survival compared with other races and ethnicities.2-4 However, the categorization of Asian ethnicities as a single race appears inappropriate, given that Asians are a culturally diverse mix . The age-adjusted incidence rate for gastric cancer in the United States for the years 2013 to 2017 was 7.3 persons per 100,000 population. J Cancer 2019; 10(4):779-788. doi:10.7150/jca.29073 This issue. 1. Despite its decreasing trend in Japan, gastric cancer remains an important public health problem. From 2014-2018, Asian/Pacific Islander men were 50 percent less likely to have prostate cancer, as compared to non-Hispanic white men, but they were 70 percent more likely to have stomach cancer. FIGC is characterized by intestinal-type gastric cancer and follows an autosomal dominant inheritance pattern. Methods: Sixteen pure bred New Zealand rabbits were equally divided into the normal control group, the low dose SD group (at the daily dose of 7 mL/kg . A majority of Chinese, Korean and Vietnamese Americans are immigrants. The proportion of early gastric cancer stages is increasing, as is the incidence of gastric cancer among the elderly population. Asian Pac J Cancer Prev. Arch Iran Med. These observations were validated by Zhou et al[ 57 ] in a large sample of the Chinese population (1686 gastric cancer patients and 1895 cancer-free subjects). Research Paper. Cancer is the second leading cause of death in the United States, yet trends and current patterns in the mortality burden of cancer among AA ethnic groups have not . In females in the UK, stomach cancer is the 15th most common cause of cancer death, with around 1,500 . To get a more precise estimation on the possible association, we performed a meta-analysis of published data. Gastric cancer incidence rates vary dramatically by world region with East Asia having the highest rate. D2 gastrectomy, which was established in the 1950s in Japan, has . H pylori is a class I carcinogen and responsible for 60 % - 80 % . This frequency was not statistically different from that in the TCGA non-Asian GC population (19 of 212 cases, 9.0%; P = 1.0000, Fisher's exact test). Herein, we aimed at establishing a novel glycolysis-related gene expression signature to predict the prognosis of GI cancers. 2014;17(7):514-520. In conclusion, the meta-analysis suggests that null genotype of GSTT1 contributes to increased risk of gastric cancer in Asian population. To tackle the problems of infiltration and heterogeneity, more accurate biomarkers for diagnosis and prognosis as well as effective targets for treatment are needed to achieve better outcomes of gastric cancer . Although gastric cancer is not in the top 10 malignancies ranked by either incidence or mortality in the United States, it does represent the second most common cause of cancer death worldwide. Since 2008, the Asian Pacific Consensus on gastric cancer prevention has suggested eradication of H. pylori in high-risk populations to prevent gastric cancer . The first review study on association of DNA methylation with gastric cancer in Iranian population. 2Department of Laboratory Medicine, St. Michael's hospital, University of Toronto. Cancer of the gastric cardia is rising in incidence in an Asian population and is associated with adverse outcome Similar to western societies, the incidence of proximal gastric cancer is increasing in Singapore. [] Mortality rates for gastric cancer have been declining worldwide in recent decades, most prominently in the United States. We conducted this study to clarify the technical feasibility and postoperative outcomes of laparoscopy-assisted distal gastrectomy (LADG) for early gastric cancer (EGC) in overweight patients. Nomura AM, Hankin JH, Kolonel LN, Wilkens LR, Goodman MT, Stemmermann GN. Design Data were extracted from population-based cancer registries. Cancer doesn't affect every racial and ethnic group in the same way, and Asian/Pacific Islander Americans face unique issues. More than 50% of cases occur in Eastern Asia. Our recent meta-analysis suggests that the p53 codon 72 polymorphism may be associated with gastric cancer among Asians. There are around 4,300 stomach cancer deaths in the UK every year, that's 12 every day (2016-2018). Objective: To observe the proliferation changes of the side population of gastric cancer cell line SGC-7901 cells (SP), the non-side population (NSP) cells, and unsorted cells (Total) after intervened by Sijunzi Decoction (SD) containing serum. Articles referenced by this article (44) We estimated odds ratios and 95% confidence intervals (CI) for associations with GIM risk using logistic . Studies have also shown that Asian Americans have lower rates of cancer screening compared to other groups in the United States. The Asian countries with a high-risk of stomach cancer, specifically Korea, Japan, China, and the Philippines, were selected due to their geographical proximity and cultural similarities. Objectives Data from population-based cancer registries contribute to improving our knowledge of digestive cancer trends worldwide. Massarrat S, Stolte M. Development of gastric cancer and its prevention. Few Asian countries have implemented a national screening . References . GC is the second leading cause of cancer death in both sexes worldwide. [2,3] The mortality rate for White males in the United States was approximately . When miR-146aCG + GG and miR-499AA genotypes were combined, the survival rate of intestinal-type gastric cancer patients was elevated (log-rank P G) and prognosis (miR-146aC>G and miR-499A>G) in . Asian Americans generally have lower cancer rates than the non-Hispanic white population. Globally, gastrointestinal (GI) cancer is one of the most prevalent malignant tumors. Diet and environmental factors In addition to H. pylori infection, the association between diet and gastric cancer risk has been widely investigated, but with controversial results. Google Scholar 106. D2 gastrectomy, which was established in the 1950s in Japan, has . Hua HB, Yan TT, Sun QM. Around the world, gastric cancer is the fourth most common cancer and the second leading cause of death. However, there has been no independent confirmation of the role of IL-1B markers in gastric cancer patients from Asian populations. Death from stomach cancer accounted for . Aim: The objective of this study was to investigate the association between p53 codon 72 polymorphism and gastric cancer risk in Chinese . Rahimi Z, Yari K, Rahimi Z. Matrix metalloproteinase-9 -1562T allele and its combination with MMP-2 -735 C allele are risk factors for breast cancer. Purpose: A previous meta-analysis (MA) published in 2009 reported that excess body weight was associated with an increased risk of gastric cancer in non-Asians, but not in Asians. In this study, we present cancer incidence and mortality in Guadeloupe, French Guiana and Martinique for the periods 2008-2014, 2010-2014 and 2007-2014, respectively. The most provocative finding is that Asian race serves as an independent predictor of gastric cancer survival. Japan, Chile, and Venezuela have developed a very rigorous early screening program that detects patients with early-stage disease (ie, low tumor burden). Asian Americans generally have lower cancer rates than the non-Hispanic white population. renquan_lu@dfci.harvard.edu Gastric cancer incidence rates vary dramatically by world region with East Asia having the highest rate. The prevalence of and deaths caused by stomach cancer are . Full text links . Moreover, there have been conflicting data regarding the effect of IL-1B-511/-31 on the risk of gastric cancer or its precursors in Asian populations. Gastric cancer (GC) poses a burden to patients across the globe as the third leading cause of cancer deaths worldwide. In high incidence countries, such as Portugal and Japan, FIGC is diagnosed if three criteria are met: 1) at least three . Intestinal Metaplasia and the Risk of Gastric Cancer in an Immigrant Asian Population.pdf Available via license: CC BY-NC 4.0 Content may be subject to copyright. . From 2014-2018, Asian/Pacific Islander men were 50 percent less likely to have prostate cancer, as compared to non-Hispanic white men, but they were 70 percent more likely to have stomach cancer. Stomach cancer is the 14th most common cause of cancer death in the UK, accounting for 3% of all cancer deaths (2018). Cases had GIM on ≥1 gastric biopsy histopathology, whereas controls lacked GIM on any biopsy. Asian Pacific J Cancer Prevent APJCP 18(11):3025-3029. Introduction. 35 Current FIGC diagnostic criteria 48 is stratified on the basis of the population gastric cancer incidence. •The burden of gastric cancer is declining both in the United States and worldwide -- but remains 2nd leading cause of cancer mortality throughout the world •Gastric cancer represents an ideal disease to demonstrate the differences between Asian and Western patients in terms of: -Incidence -Prognosis/clinical outcomes -Therapeutic . Introduction. Attar M, Mansoori M, Shahbazi M (2017) Interleukin-6 genetic variation and susceptibility to gastric cancer in an Iranian population. Within the Asian American community, Korean Americans are the least likely to undergo screenings for colon, cervical and breast cancer. Therapeutic options for advanced gastric cancers have been enormously improved. The rates of gastric cancer are higher in Asian and South American countries than in the United States; in Japan, for example, stomach cancer is the most common cancer site in males. Within the Asian American population as a whole, cancer affects people of different national origins differently. We further analyzed differential regulatory patterns related to these featured genes, such as C1S, and suggested hypotheses for investigating their roles in gastric cancer pathogenesis. Gastric cancer is the third leading cause of cancer death and the fifth most common cancer worldwide, with some of the highest incidence and mortality rates found in the Eastern Asian countries of China, Japan, and Korea [].In the United States (US), the fastest growing minority population is Asian American, due to an immigration surge from these and other Asian countries, including India . Accurate classification Risk factors for gastric cancer are Helicobacter pylori (H pylori) infection, host genetic factors and environmental factors. 2016;17(5):2499-506. The remaining 6 Asian countries not shown are also excluded from Rest of world. Read article at publisher's site (DOI): 10.1007/s13277-013-0669-3. 1, 2 Therefore, the advances we make in gastric cancer treatment, even in low-incidence countries, can have global implications. Gastric cancer is the second most common cause of death from cancer in Asia. Furthermore, we also conduct a simple meta-analysis about most frequently studied miRNA-SNPs (rs11614913 in miR-196a-2, rs895819 in miR-27a and rs2910164 in miR-146a) in gastric cancer. In the last two decades, the 5-year survival rate is up to 40%. A large proportion of Japanese gastric cancers are detected at an early stage, with a better overall survival rate. Rate of New Cases and Deaths per 100,000: The rate of new cases of stomach cancer was 7.2 per 100,000 men and women per year. In North America, this incidence is 5.6 per 100,000. The population of Japan is aging year by year. INTRODUCTION. As the populations in Asian and Latin American countries continue to age, the probability of more diagnoses also increases. Lin SH, Li YH, Leung K, Huang CY, Wang XR. Chemoprevention of gastric cancer development after Helicobacter pylori eradication therapy in an East Asian population: Meta-analysis In the East Asian population with a high risk of GC, <i>H. pylori</i> eradication effectively reduced the risk of GC, irrespective of past history of previous cancer. Surgical Compliance and Outcomes in Gastric Cancer: a population-based cohort study . In contrast, the study conducted by Hishida et al on 583 gastric cancer cases and 540 gastric atrophy cases suggested a lack of association between SNP rs2910164 and gastric cancer risk. METHODS: We identified patients who had undergone esophagogastroduodenoscopy with gastric biopsy from 3/2006-11/2016 using the pathology database at a safety net hospital in Houston, Texas. The inhibition rate of gastric cancer cells after treatment with curcumin was increased from 6% to 67% for 24h, from 8% to 75% for 48h, from 10% to 83% for 72h. Gastric cancer (GC) is a global health problem, with more than 1 million people newly diagnosed with GC worldwide each year. There were obvious inconclusive results among those studies, which were probably due to limited sample sizes, ethnic difference or publication bias [10-20, 26-41]. Aim and Objective: Gastric cancer is one of the most common cancers and has very high incidence and mortality rate in Asian population. Incidence of GC is particularly high in Asian countries, which is attributed to the prevalence of Helicobacter pylori (H. pylori) infection and has prompted the establishment of unique treatment strategies. Caution must be exercised, however, in applying findings . The 9 Asian countries represented are those contributing 1% or more of the world's total new cancer cases or 1% or more of the specific cancer listed. Although surgery is the standard treatment for this disease, early detection and treatment is the only way to reduce mortality. This Review summarises the epidemiology of gastric cancer, and the evidence for, and current practices of, screening in Asia. Incidence of GC is particularly high in Asian countries, which is attributed to the prevalence of Helicobacter pylori (H. pylori) infection and has prompted the establishment of unique treatment strategies. Background: Asian Americans (AA) are the fastest growing U.S. population, and when properly distinguished by their ethnic origins, exhibit substantial heterogeneity in socioeconomic status, health behaviors, and health outcomes. Background: Asian Americans (AA) are the fastest growing U.S. population, and when properly distinguished by their ethnic origins, exhibit substantial heterogeneity in socioeconomic status, health behaviors, and health outcomes. This large population-based study will serve as a platform for developing future work to better understand factors involved in long-term survivors of gastric cancer, including genetic, genomic, and survivorship studies. Indeed, the age-standardized rates of both of these malignancies are also considerably higher in East Asia compared to western countries, consistent with previous . A functional polymorphism of lymphotoxin-alpha (LTA) gene rs909253 is associated with gastric cancer risk in an Asian population . However, studies have not established glycolysis-related gene signatures that can be used to construct accurate prognostic models for GI cancers in the Asian population. Two cancers found at a much higher rate among Asian Americans than among NHWs are stomach and liver cancer, the report notes. Background: Globally, Asian countries bear a disproportionate gastric cancer burden. Racial differences in Helicobacter pylori, serum pepsinogen and gastric cancer incidence in an urban Asian population J Gastroenterol Hepatol . Results: We identified a 36-gene prognostic signature specific for gastric cancer, particularly for Asian population. 10. However, disparities still exist in certain types of cancer. Projections for the future predict that gastric cancer incidence will continue to rise. Purpose It is generally considered difficult to operate on overweight patients, who are also at increased risk of postoperative complications. Countries With The Highest Prevalence Of Stomach Cancer . Objective A global consensus meeting was held to review current evidence and knowledge gaps and propose collaborative studies on population-wide screening and eradication of Helicobacter pylori for prevention of gastric cancer (GC). 2 Gastric cancer, with an annual incidence of 7300, is one of the five most common cancers in Iranian men and . Introduction. The present meta-analysis results suggest that the LTA rs909253 GA genotype is a possible risk factor for developing gastric cancer in the Asian population, especially those with H. pylori infection. However, disparities still exist in certain types of cancer. Non-Hispanic whites in Los Angeles were included as the reference group. "Gastric cancer in the third-line setting is a particularly hard-to-treat and heterogeneous disease, and importantly, this was the first trial conducted with a checkpoint inhibitor compared to an . Incidence among men was twice as high as among women. In the US in 2011, there were an estimated 74,035 people living with stomach cancer [4] and the estimated age adjusted incidence rate is about 22.22 cas- es/100,000 population in the year 2014 (1.3% of all new cancer cases in the US) making it the 16th common cancer in the US. Overall, there are fewer cases of cancer in Asian/Pacific Islander men and women than in most other races. Methods 28 experts from 11 countries reviewed the evidence and modified the statements using the Delphi method, with consensus level predefined as ≥80% of . These observations were validated by Zhou et al [ 57 ] in a large sample of the Chinese population (1686 gastric cancer patients and 1895 cancer-free subjects). Gastric cancer is one of the most common cancers in the world, 1 with the highest incidence in the countries of Western Asia, Latin America, and the former Soviet Union. According to reported studies ( 31, 32 ), it has also been concluded that frequencies of BRCA1/2 pathogenic variants among general Japanese and West European populations are almost comparable.
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