Background: Outcomes with prasugrel single antiplatelet therapy (SAPT) vs. dual antiplatelet therapy (DAPT) in Japanese percutaneous coronary intervention (PCI) patients with high bleeding risk (HBR) are currently unknown. J Clin Biochem Nutr. Methods and Results:Data from 1,173 SAPT and 2,535 DAPT patients from the PENDULUM mono and PENDULUM registry The results of these studies might provide evidence for a benefit of single antiplatelet therapy in patients with SCAD or ACS, and change the paradigm of antiplatelet therapy after PCI. The following are key points to remember about the updated guideline on duration of dual antiplatelet therapy (DAPT) in patients with coronary artery disease (CAD): The scope of this focused update is limited to addressing recommendations on duration of DAPT (aspirin plus a P2Y 12 inhibitor) in patients with coronary artery disease (CAD). Take part in … The recently published trials of AF patients undergoing PCI have shown that combination of non-vitamin K oral anticoagulants (NOACs) with an antiplatelet agent is either superior or non-inferior to vitamin K antagonist (VKA) plus dual antiplatelet therapy (DAPT) in reducing bleeding complications wi … Am J Cardiovasc Drugs (2016) 16:103–110 DOI 10.1007/s40256-015-0154-z SYSTEMATIC REVIEW Meta-Analysis of Oral Anticoagulants with Dual versus Single Antiplatelet Therapy in Patients after Percutaneous Coronary Intervention 1 2,3 3 • • • Alexandros Briasoulis Nikolaos Papageorgiou Efimia Zacharia 1 1 3,4 • • • Mohan Palla Mohamad Darwich El … Objectives: Aim of this study was to assess the effect of early initiation of high bolus dose tirofiban on top of dual antiplatelet therapy on angiographic outcome before and after primary percutaneous coronary intervention (PCI) in ST-elevation myocardial infraction patients. Dual antiplatelet therapy (DAPT) consisting of aspirin and a P2Y 12 in hibitor is prescribed in the treatment of acute coronary syndrome (ACS) or following percutaneous coronary intervention (PCI) for drug-eluting stent (DES) implantation.An important misconception remains that DAPT should be prescribed to prevent stent thrombosis. Nature Publishing Group. [2020] Also see the NICE technology appraisal guidance on rivaroxaban for preventing adverse outcomes after management of acute coronary syndromes . For patients at high bleeding risk, which was recently defined by the Academic Research Consortium-High Bleeding Risk (ARC-HBR) group, they recommend 1 month of DAPT followed by a single antiplatelet agent. Despite a large volume of evidence supporting the use of dual antiplatelet therapy in patients with acute coronary syndrome, there remains major uncertainty regarding the optimal duration of therapy. Ticagrelor 90 mg twice a day. Aspirin is the recommendation of choice for antiplatelet monotherapy and clopidogrel is recommended as an alternative in patients who do not tolerate aspirin therapy. These recommendations are based on clinical trials demonstrating that DAPT … Category Dual Therapy (N = 100) ASA Therapy (N = 100) p-Value β-Blocker Use 85 80 0.35 ICU Hours ± SD 49.5 ± 47.9 55.06 ± 36 0.36 LOS (days) ± SD 7.14 ± 3.7 6.88 ± 3 0.59 Prior CVA/TIA 15 5 0.018 This article presents the patients, which had to be given single antiplatelet therapy … Participants 1008 consecutive PCI patients with stent implantation, without exclusion criteria. An assessment of the thrombotic risk of the patient is considered first. ...Next the bleeding risk of the procedure is ascertained. ...If the bleeding risk is low and thrombotic risk is high, it is probably worth continuing the single or dual antiplatelet therapy (especially if a coronary stent was inserted in ...More items... Cardiology, 14(5), 294 - 303. T he optimal duration of dual antiplatelet therapy (DAPT) following percutaneous coronary intervention (PCI) has been the subject of intense study and debate for years now. Nature Reviews Cardiology, Volume 14 - Issue 5 p. 294- 303 The optimal duration and type of antiplatelet therapy after implantation of a drug-eluting stent (DES) remains uncertain. Summary By: Bina Ahmed, MD, FACC Patients should receive the standard duration (12 months) of dual antiplatelet therapy (DAPT) after percutaneous coronary intervention with drug-eluting stent implantation. Multiple trials investigating a shorter or longer duration of DAPT have been published, but most were underpowered and limited by open-label methodology. 10 The presence of Atrial Fibrillation (AF), mechanical heart valves and thombotic events may necessitate the need for anticoagulation. N Engl J Med 2017;377:1513-24 Dewilde WJ, Oirbans T, et al. Dual antiplatelet therapy (DAPT), comprising aspirin and a P2Y 12 receptor inhibitor, is the cornerstone of treatment in patients who have undergone percutaneous coronary intervention (PCI). Setting Tertiary care single centre registry. Objective: To assess the impact of dual antiplatelet (DAP) therapy of .12 months on long-term death and myocardial infarction (MI) after percutaneous coronary intervention (PCI). : Dual antiplatelet therapy does not affect the incidence of low-dose aspirin-induced small intestinal mucosal injury in patients after percutaneous coronary intervention for coronary stenosis: a multicenter cross-sectional study. Risk of bias assessment. Question ... Risk of Bleeding with Single, Dual, or Triple Therapy in Patients with Atrial Fibrillation • Nationwide Danish registry • 118,606 patients with AF ... OAC undergoing PCI WOEST Trial 573 patients TOAT 1852 patients with dual antiplatelet therapy after PCI in coronary heart disease. Please help EMBL-EBI keep the data flowing to the scientific community! Anti-thrombotic treatment is very important for secondary prevention. Prasugrel and ticagrelor have more potent and consistent platelet inhibition … Study design Retrospective analysis of 3342 patients who underwent PCI between 1 August 2011 and 31 December 2018 in a single centre … Design, setting and patients: Prospective, single-centre, observational study of 1859 consecutive patients who underwent successful PCI of a native coronary artery Methods and Results:Data from 1,173 SAPT and 2,535 DAPT patients from the PENDULUM mono and PENDULUM registry 1 2 3 The recommended duration of DAPT for patients after drug-eluting stent (DES) implantation is ≥12 months for patients with acute coronary syndrome (ACS), and six months for patients with … Standard 12 months of DAPT following PCI (and subsequent maintenance [12 month] antiplatelet therapy with ASA) with A new regimen involving 30 days of DAPT with ASA + ticagrelor (and subsequent maintenance [23 month] therapy with ticagrelor) In an all-comers population undergoing PCI with unrestricted biolimus eluting stent (BES) use However, some … Dual antiplatelet therapy (DAPT), with aspirin and a P2Y 12-receptor inhibitor, is a basis for the care of patients after percutaneous coronary intervention (PCI). Dual antiplatelet therapy (DAPT) provides more intense platelet inhibition than single antiplatelet therapy resulting in incremental reductions in the risk of thrombotic events after percutaneous coronary intervention (PCI) or ACS, but it has been associated with an increased risk of major bleeding.2–5 The choice of optimal DAPT regimen and Extended dual antiplatelet therapy after PCI with DES a meta-analysis of randomized trials Cassese S, Kastrati A, EHJ 2013. Among patients undergoing PCI, dual antiplatelet therapy (aspirin plus a P2Y12 inhibitor) reduces the risk of blood clots and heart attacks but also increases the risk of bleeding. Purpose of study This study examines the associations between dual antiplatelet therapy (DAPT) after percutaneous coronary intervention (PCI) and gastrointestinal bleeding (GIB), to explore possible predictors of outcomes. In their editorial, Baber and Angiolillo attempt to provide some insight into the expanding evidence base for antiplatelet therapy after PCI. Several clinical and angiographic variables are associated with an increased risk for thrombotic events, and prolonged DAPT duration may improve long term clinical outcome. Nature Publishing Group. Objective To evaluate the clinical utility of individualising dual antiplatelet therapy (DAPT) after percutaneous coronary intervention (PCI) in an all-comers population, including ST-elevation myocardial infarction (STEMI) patients. Dual antiplatelet therapy (DAPT), defined as the use of a P2Y12 receptor inhibitor (clopidogrel, ticagrelor or prasugrel) and aspirin, is required after percutaneous coronary intervention (PCI) with drug-eluting stents (DES).1 Although the use of DES has been shown to reduce the rate of restenosis as compared with bare-metal stents (BMS), there is concern that DES may be … The optimal duration of dual antiplatelet therapy (DAPT) after percutaneous coronary intervention (PCI) remains an important clinical question in interventional cardiology. Of these patients, the rate of gastrointestinal bleeding was 2.7%.19 Rational for single antiplatelet therapy Accumulative evidence indicated that DAPT may increase the risk of gastrointestinal bleeding.20 Of note, this inferiority may induce bleeding-related death. Coronary artery disease (CAD) is the second leading cause of death in Japan (15.2%), and the incidence of ischemic heart disease (IHD) in Japan is increasing, with more than 200,000 deaths due to heart disease (excluding hypertension) reported in 2017 [].Percutaneous coronary intervention (PCI) is the primary treatment for IHD [], and dual antiplatelet therapy … Relevant for : Treatment(s) now being considered … Patients concomitantly receiving OAC could maintain dual antiplatelet therapy until a year had passed (triple scheme) or discontinue it three months after angioplasty and complete the year with a single antiplatelet agent (aspirin or a P2Y12 inhibitor). Subsequently, DAPT duration was extended to 1 year on the basis of anecdotal historical data, … 15. Single versus Dual Antiplatelet Therapy after CABG Surgery Open Access OJTS 138 Table 3. Dual antiplatelet therapy including aspirin and a P2Y12 ADP receptor antagonist is given after percutaneous coronary intervention to avoid catastrophic complication of stent thrombosis. Dual antithrombotic therapy with dabigatran after PCI in atrial fibrillation. doi: 10.1001/jama.2016.3775 Crossref Medline Google Scholar; 3. Longer DAPT duration has been demonstrated to reduce the chances for ischemic outcomes at the expense of an increase in clinically relevant bleeding. Cardiology, 14(5), 294 - 303. In general, the use of “triple therapy” (dual antiplatelet therapy plus anticoagulation) is not … Antiplatelet therapy has been considered the standard treatment for secondary prevention of ischemic events and mortality after acute myocardial infarction (AMI) [1, 2].The benefit of dual antiplatelet therapy (DAPT) has been established in the Clopidogrel in Unstable Angina to Prevent Recurrent Events (CURE) trial, which showed improved outcomes among … Two trials have compared 1 month of dual antiplatelet therapy with at least 12 months of dual antiplatelet therapy after PCI with drug-eluting stents. Eur Heart J 2020;Dec 7:[Epub ahead of print]. Dual antiplatelet therapy (DAPT) in patients with MI who are candidates for early coronary artery bypass grafting (CABG) can affect intraoperative and postoperative outcomes. Objectives The purpose of this analysis was to compare 1 vs 3 months of DAPT in HBR patients undergoing drug-eluting stent implantation. DAPT: dual antiplatelet therapy OAC: oral anticoagulant therapy. An early switch from dual antiplatelet therapy (DAPT) to single antiplatelet therapy (SAPT) up to 3 (-6) months after PCI has been so far the domain in patients with high-bleeding risk (HBR) and is supported in the recent ESC Clinical Practice Guidelines. Cannon CP, Bhatt DL, et al. Abstract. 4-8 A shorter duration of dual antiplatelet followed by single antiplatelet therapy with a P2Y12 inhibitor might reduce adverse events with no increase in bleeding. Secondary analysis. Title: Single or dual antiplatelet therapy after PCI: Published in: Nature reviews. Table 2 of the supplementary data shows the results of the risk of bias assessment using the RoB 2.0 tool. Although this may seem obvious, it should … After peripheral revascularisation transient dual antiplatelet therapy is widely … Percutaneous coronary intervention, usually with stenting, performed within 90 min of first medical contact, is the treatment of choice for most patients presenting with STEMI. 3,4 Aspirin monotherapy or DAPT may also be used to prevent major adverse cardiovascular events for patients with peripheral artery disease. Dual antiplatelet therapy (DAPT), aspirin and a P2Y12 inhibitor, is the cornerstone to prevent the stent thrombosis and reduce ischemic events after … 9. SYNOPSIS: In this randomized trial that included more 3,000 patients, one month of dual antiplatelet therapy (DAPT) followed by single antiplatelet therapy with clopidogrel was noninferior to 12 months of DAPT following percutaneous coronary intervention with … DAPT, dual antiplatelet therapy; SAPT, single antiplatelet therapy; TAVI, transcatheter aortic valve implantation. Development and validation of a prediction rule for benefit and harm of dual antiplatelet therapy beyond 1 year after percutaneous coronary intervention. Abstract. Objective: To assess the impact of dual antiplatelet (DAP) therapy of .12 months on long-term death and myocardial infarction (MI) after percutaneous coronary intervention (PCI). Purpose: To determine the incidence and risk factors of bleeding events as well as assess the performance of the PRECISE-DAPT score in elderly patients (≥75 years) who underwent percutaneous coronary intervention (PCI) and one-year dual antiplatelet therapy (DAPT).Methods: A total of 940 patients (≥75 years) who received PCI and one-year DAPT were … At the time of the first-in-man implantation of the sirolimus DES in 1999, the protocol-defined dual antiplatelet therapy (DAPT) duration was only 2 months. Objectives. Meanwhile, international guidelines and clinical practice recommend dual antiplatelet therapy (DAPT aspirin combination with P2Y12 inhibitors) after PCI. 2018, 63:224-9. Antiplatelet therapy has been considered the standard treatment for secondary prevention of ischemic events and mortality after acute myocardial infarction (AMI) [1, 2].The benefit of dual antiplatelet therapy (DAPT) has been established in the Clopidogrel in Unstable Angina to Prevent Recurrent Events (CURE) trial, which showed improved outcomes among … 10.3164/jcbn.18-16 16. Aspirin is often combined with a P2Y12 receptor antagonist (clopidogrel, prasugrel, or ticagrelor) for dual antiplatelet therapy (DAPT) after PCI or ACS. Hara A, Ota K, Takeuchi T, et al. Several recent randomized trials suggest that abbreviated dual antiplatelet therapy (DAPT; aspirin plus a platelet P2Y 12 receptor antagonist) can reduce the risk for bleeding without increasing the risk for thrombotic events after percutaneous coronary intervention (PCI) with stent placement. 2016 Sep 6;134[10]:e123-55).In an analysis of the available data, the authors of those guidelines … Why do I need antiplatelet therapy?Coronary artery disease (CAD)Heart attackAnginaStroke or transient ischemic attacks (TIAs)Peripheral vascular disease (PVD) 1852 patients with dual antiplatelet therapy after PCI in coronary heart disease. Dual antiplatelet therapy DAPT refers to that combination of antiplatelet therapy combining ASA with a P2T12 receptor inhibitor (clopidogrel, prasugrel, or ticagrelor). Rationale: Dual antiplatelet therapy (DAPT), consisting of aspirin and a P2Y12-inhibitor, reduces the risk of stent thrombosis, myocardial infarction and stroke after coronary stent implantation. Discontinuation of long term clopidogrel therapy induces platelet rebound hyperaggregability … Single or dual antiplatelet therapy after PCI. ing risk receiving 1 month of dual antiplatelet therapy after undergoing percutaneous coronary intervention (PCI). 1,2 Clopidogrel was the first broadly used P2Y 12 receptor inhibitor and conferred a significant reduction in ischemic events after PCI. After percutaneous coronary intervention, standard therapy is dual antiplatelet therapy for 6–12 months followed by indefinite duration of antiplatelet monotherapy. Among patients who completed 6 months of dual antiplatelet therapy (DAPT) after successful percutaneous coronary intervention (PCI), gastrointestinal injury was lower in those who replaced DAPT with single antiplatelet therapy (SAPT) for the next 6 months, the OPT-PEACE randomized trial showed.. Gastrointestinal mucosal injury including ulcerations, bleeding, and … All-cause mortality and efficacy outcomes in patients treated with SAPT compared to DAPT after TAVI. Introduction. "Patients at high bleeding risk undergoing PCI should thus be considered for SAPT [single antiplatelet therapy] after 1-3 months of DAPT after … Recurrent stroke after ischemic stroke (IS) or high-risk transient ischemic attack (TIA) increases morbidity and mortality. Dual antiplatelet therapy (DAPT) with aspirin (ASA) and a P2Y12 inhibitor (clopidogrel, ticagrelor, or prasugrel) is a standard therapeutic regimen to prevent stent thrombosis after percutaneous coronary intervention (PCI) with drug-eluting stents (DESs). Single versus Dual Antiplatelet Therapy. Commonly, after an acute coronary syndrome (ACS) or after percutaneous coronary interventions (PCI) or even bypass surgery, dual antiplatelet therapy (DAPT) is recommended consisting of aspirin plus a P 2 Y 12 inhibitor. Strategies to avoid bleeding complications in such patients include proper assessment of bleeding risks with validated risk predictors like the HAS-BLED score, keeping triple therapy as short as possible, consider dual therapy with OAC with clopidogrel (preferred) instead of triple therapy, consider use of novel OACs instead of Vit-K antagonists when not … In this review, we focus on DAPT indications, combinations, … The combo of just one anticoagulation with warfarin and a one antiplatelet agent had way fewer bleeding events with no signal for increased thrombotic risk. Design, setting and patients: Prospective, single-centre, observational study of 1859 consecutive patients who underwent successful PCI of a native coronary artery Affiliations. The first place to start is the WOEST trial from 2013,which randomized patients who were already on warfarin and underwent a PCI to single antiplatelet therapy versus dual antiplatelet. Dual antiplatelet therapy (DAPT) with acetylsalicylic acid (aspirin) and a platelet P2Y12 receptor antagonist is the standard of care for prevention of thrombus formation within a stent, i.e., stent thrombosis (ST), after percutaneous coronary intervention (PCI). JAMA. 1. Percutaneous coronary intervention (PCI). Short Dual Antiplatelet Therapy Followed by P2Y 12 Inhibitor Monotherapy vs. Recent American College of Cardiology and European Society of Cardiology Guidelines recommend dual antiplatelet therapy (DAPT) with aspirin and one of the P2Y 12 inhibitors as a standard regimen after percutaneous coronary intervention (PCI) with or without stenting. After percutaneous coronary intervention (PCI) with drug-eluting stent (DES) implantation, dual antiplatelet therapy (DAPT) with aspirin and a P2Y 12 receptor inhibitor is the standard treatment to prevent stent thrombosis. Background: There is ongoing debate regarding the optimal antiplatelet strategy beyond 12 months in patients with acute myocardial infarction (AMI) who undergo successful percutaneous coronary intervention (PCI). The optimal duration of dual antiplatelet therapy (DAPT) after percutaneous coronary intervention (PCI) among patients at high bleeding risk (HBR) is unknown. ISSN 1759-5010. 4,5 Previous clinical application indicated that DES reduced major advent cardiac such as death, non-fatal myocardial infarction target lesion revascularization. Patients with a diagnosis of non valvular atrial fibrillation (or atrial flutter treated) with PCI and stent (drug eluting or bare metal stent) requiring triple antithrombotic therapy (double antiplatelets agents and oral anticoagulation) or dual antithrombotic therapy (single antiplatelet agent and oral … Dual antiplatelet therapy including aspirin and a P2Y 12 ADP receptor antagonist is given after percutaneous coronary intervention to avoid catastrophic complication of stent thrombosis.Dual antiplatelet therapy is associated with increased bleeding risk and may not be tolerated by many patients. At the time of the first-in-man implantation of the sirolimus DES in 1999, the protocol-defined dual antiplatelet therapy (DAPT) duration was only 2 months. 2016; 315:1735–1749. Dual antiplatelet therapy (DAPT), with aspirin and a P2Y 12 receptor inhibitor, is a basis for the care of patients after percutaneous coronary intervention (PCI).1-3 The recommended duration of DAPT for patients after drug-eluting stent (DES) implantation is ≥12 months for patients with acute coronary syndrome This study therefore aimed to investigate the clinical outcomes of single (SAPT) vs. dual antiplatelet therapy (DAPT) beyond 12 months in patients with stable … However, these studies have not focused specifically on high-bleeding-risk patients, … Dual antiplatelet therapy (DAPT), with aspirin and a P2Y 12-receptor inhibitor, is a basis for the care of patients after percutaneous coronary intervention (PCI).1 2 3 The recommended duration of DAPT for patients after drug-eluting stent (DES) implantation is ≥12 months for patients with acute coronary syndrome (ACS), and six months for patients with … Secondary stroke prevention strategies include modification of behavioral and vascular risk factors and antithrombotic use, including single or dual antiplatelet therapy (DAPT). Among patients who received 6 months of dual antiplatelet therapy (DAPT) following percutaneous coronary intervention (PCI), switching to a single antiplatelet therapy (SAPT) regimen for another 6 months resulted in less gastrointestinal (GI) injury than continuing DAPT, results of the OPT-PEACE trial showed. Single or dual antiplatelet therapy after PCI Publication Publication. Miyazaki Y 1, Suwannasom P 2, Sotomi Y 2, Abdelghani M 2, Tummala K 3, Katagiri Y 2, Asano T 2, Tenekecioglu E 1, Zeng Y 1, Cavalcante R 1, Collet C 2, Onuma Y 1, Serruys PW 4. In this prospective cohort study, 224 … Title: Single or dual antiplatelet therapy after PCI: Published in: Nature reviews. 15 Antiplatelet therapy is used before, during, and after PCI to reduce the risk of peri-procedural and post-procedural ischaemic events. Dual antiplatelet therapy (DAPT) combining aspirin and a P2Y12 receptor inhibitor has been consistently shown to reduce recurrent major adverse cardiovascular events (MACE) in patients with acute coronary syndrome (ACS) or undergoing percutaneous coronary intervention (PCI) for stable coronary artery disease (CAD) compared with aspirin monotherapy, but at the … Clinical trials have varied markedly in the duration of therapy, both across and within trials. It found that single APT (SAPT) resulted in a lower risk of bleeding compared to dual APT (DAPT). Prolonged Dual Antiplatelet Therapy After Percutaneous Coronary Intervention With Second-Generation Drug-Eluting Stents: A Systematic Review and Meta-Analysis of Randomized Clinical Trials. The safety and efficacy of oral anticoagulants with dual versus single antiplatelet therapy in patients after percutaneous coronary intervention: A meta-analysis. 1-3 Nevertheless, these trials were not designed to assess the appropriate duration of dual antiplatelet therapy after the implantation of a drug-eluting stent. The optimal duration and type of antiplatelet therapy after implantation of a drug-eluting stent (DES) remains uncertain. Concomitant anticoagulation with Dual Antiplatelet Therapy (DAPT) may be required in 6-8% of patients who require Percutaneous Coronary Intervention (PCI) due to other coexisting conditions . Inevitably, it is also associated with a higher risk of (major) bleeding. 5 authors. This study looked at the outcomes of patients treated with single or double long-term antiplatelet therapy (APT) after a percutaneous coronary intervention (PCI) using second-generation drug-eluting stents (DES). The reorientation toward limiting DAPT to the acute risk of thrombosis after PCI is reflected in the recently published 2016 American College of Cardiology/American Heart Association Guideline Update on Duration of Dual Antiplatelet Therapy (Circulation. https://www.ahajournals.org/doi/10.1161/CIRCULATIONAHA.120.046308 By: Michael A. Kutcher, MD, FSCAI, and Faisal Latif, MD, FACC, FSCAI. Setting Tertiary care single centre registry. ISSN 1759-5010. Recent systematic reviews and meta-analyses suggest that shorter durations of dual … Therefore, the aim of this study was to evaluate the effect of DAPT up to the day before CABG on the outcomes during and after surgery in patients with MI. 1.1.25 Consider clopidogrel, as part of dual antiplatelet therapy with aspirin, or aspirin alone, for people with acute STEMI not treated with PCI, if they have a high bleeding risk. The optimal duration and type of antiplatelet therapy after implantation of a drug-eluting stent (DES) remains uncertain. One month of dual antiplatelet therapy after PCI non-inferior to standard duration: results from MASTER DAPT. Author information. Background: Outcomes with prasugrel single antiplatelet therapy (SAPT) vs. dual antiplatelet therapy (DAPT) in Japanese percutaneous coronary intervention (PCI) patients with high bleeding risk (HBR) are currently unknown. Read also: Post PCI Same Day Discharge: from Convenience to Need. This article presents the patients, which had to be given single antiplatelet therapy after percutaneous coronary intervention and discusses the possible factors responsible for the success of single antiplatelet therapy strategy in these patients, in the current era of newer … Participants 1008 consecutive PCI patients with stent implantation, without exclusion criteria. In symptomatic patients single antiplatelet therapy with clopidogrel or Aspirin is recommended. Objective To evaluate the clinical utility of individualising dual antiplatelet therapy (DAPT) after percutaneous coronary intervention (PCI) in an all-comers population, including ST-elevation myocardial infarction (STEMI) patients. ... DAPT was defined as an additional 2 or 5 month duration (with or without anticoagulation, respectively) followed by single antiplatelet therapy (SAPT) for up to 11 months following randomization. Inclusion Criteria: • Patients aged 18 years or older. Of these patients, the rate of gastrointestinal bleeding was 2.7%.19 Rational for single antiplatelet therapy Accumulative evidence indicated that DAPT may increase the risk of gastrointestinal bleeding.20 Of note, this inferiority may induce bleeding-related death. In 2017, two focused updates from the European Society of Cardiology (ESC) and the American College of Cardiology/American Heart Association (ACC/AHA) set new standards for the duration of dual antiplatelet therapy (DAPT) following percutaneous coronary intervention (PCI): six months for patients with stable coronary artery disease (CAD) and 12 months for … Although the effectiveness of drug-eluting stents in those with high bleeding risk receiving dual antiplatlet therapy after percutaneous coronary intervention (PCI) is known, it is still unclear what is the appropriate duration of dual antiplatelet therapy for these patient populations.. As a result, a recent study performed a randomized trial of patients at high risk … Background: Glycoprotein IIb/IIIa inhibitors are effective inhibitors of platelet aggregation, and … Use of clopidogrel with or without aspirin in patients taking oral anticoagulant therapy and undergoing percutaneous coronary intervention: an open-label, randomised, controlled trial. We aimed to assess the ischemic and bleeding risks of single antiplatelet therapy (SAPT) with prasugrel compared with standard dual antiplatelet therapy (DAPT) (aspirin plus clopidogrel for 1 year) in patients with chronic coronary syndrome (CCS) treated with new generation drug‐eluting stents (DES).
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